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Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune    

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Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and

Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 551-561 doi: 10.1007/s11684-020-0760-2

Abstract: Several studies correlated tumor recurrence with tumor heterogeneity and the immune microenvironment.this review, we introduce the different mechanisms involved in glioma progression, including tumor heterogeneity

Keywords： glioma     evolution mechanism     strategies     tumor heterogeneity     secondary glioma    

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Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype

Xu Chen, Xiaomao Xu, Fei Xiao

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 425-432 doi: 10.1007/s11684-013-0295-x

Abstract: This review briefly describes the heterogeneity of COPD, with focus on recent advances in the correlations

Keywords： chronic obstructive pulmonary disease     heterogeneity     phenotype     genotype     prediction    

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Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between

Na Qin, Yuancheng Li, Cheng Wang, Meng Zhu, Juncheng Dai, Tongtong Hong, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Gary Goodman, Stig E. Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeboller, Gadi Rennert, Susanne Arnold, Paul Brennan, John K. Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J. Hung, Angeline Andrew, Lambertus A. Kiemeney, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Penella Woll, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Victoria L. Stevens, Guangfu Jin, David C. Christiani, Zhibin Hu, Christopher I. Amos, Hongxia Ma, Hongbing Shen

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 275-291 doi: 10.1007/s11684-020-0779-4

Abstract: Although genome-wide association studies have identified more than eighty genetic variants associatedboth well-studied and new susceptibility loci of NSCLC, providing not only novel insights into the geneticheterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional

Keywords： genome-wide association study     function annotation     immune     homologous recombination repair deficiency     geneticheterogeneity    

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Computational modeling of fracture in concrete: A review

Luthfi Muhammad Mauludin, Chahmi Oucif

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 3,   Pages 586-598 doi: 10.1007/s11709-020-0573-z

Abstract: As heterogeneity of concrete material is major concern in micromechanical-based concrete modeling, one

Keywords： concrete fracture     macroscopic     micromechanical     heterogeneity    

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Analysis of stress and failure in rock specimens with closed and open flaws on the surface

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 5,   Pages 1222-1237 doi: 10.1007/s11709-021-0773-1

Abstract: The influence of closed and open surface flaws on the stress distribution and failure in rock specimens is investigated. Heterogeneous finite element models are developed to simulate the compression tests on flawed rock specimens. The simulated specimens include those with closed flaws and those with open flaws on the surface. Systematic analyses are conducted to investigate the influences of the flaw inclination, friction coefficient and the confining stress on failure behavior. Numerical results show significant differences in the stress, displacement, and failure behavior of the closed and open flaws when they are subjected to pure compression; however, their behaviors under shear and tensile loads are similar. According to the results, when compression is the dominant mode of stress applied to the flaw surface, an open flaw may play a destressing role in the rock and relocate the stress concentration and failure zones. The presented results in this article suggest that failure at the rock surface may be managed in a favorable manner by fabricating open flaws on the rock surface. The insights gained from this research can be helpful in managing failure at the boundaries of rock structures.

Keywords： surface flaw     heterogeneity     circular hole     numerical modeling     relative displacement    

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A multiscale material model for heterogeneous liquid droplets in solid soft composites

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 5,   Pages 1292-1299 doi: 10.1007/s11709-021-0771-3

Abstract: Liquid droplets in solid soft composites have been attracting increasing attention in biological applications. In contrary with conventional composites, which are made of solid elastic inclusions, available material models for composites including liquid droplets are for highly idealized configurations and do not include all material real parameters. They are also all deterministic and do not address the uncertainties arising from droplet radius, volume fraction, dispersion and agglomeration. This research revisits the available models for liquid droplets in solid soft composites and presents a multiscale computational material model to determine their elastic moduli, considering nearly all relevant uncertainties and heterogeneities at different length scales. The effects of surface tension at droplets interface, their volume fraction, size, size polydispersity and agglomeration on elastic modulus, are considered. Different micromechanical material models are incorporated into the presented computational framework. The results clearly indicate both softening and stiffening effects of liquid droplets and show that the model can precisely predict the effective properties of liquid droplets in solid soft composites.

Keywords： liquid in solid     soft composite     computational modeling     multiscale model     heterogeneity    

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Heterogeneous influence of individuals’ behavior on mask efficacy in gathering environments

Frontiers of Engineering Management   Pages 550-562 doi: 10.1007/s42524-022-0193-5

Abstract: The heterogeneity of individuals can cause mask efficacy in a specific gathering environment to be differentFurthermore, the heterogeneity of gathering environments causes the epidemic prevention effect of masksGiven the heterogeneity of individual behavior, if individuals who are more active in terms of interpersonal

Keywords： COVID-19     masks     behavioral heterogeneity     asymptomatic infection    

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Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 768-780 doi: 10.1007/s11684-023-0982-1

Abstract: By employing echocardiography and genetic screening for the 46 genes, HCM can be classified into two

Keywords： machine learning methods     hypertrophic cardiomyopathy     genetic risk    

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Interplay between diet and genetic susceptibility in obesity and related traits

Tiange Wang, Min Xu, Yufang Bi, Guang Ning

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 601-607 doi: 10.1007/s11684-018-0648-6

Abstract: Longitudinal studies and randomized intervention trials have shown that genetic susceptibility to obesity

Keywords： diet     genetic susceptibility     obesity     interaction    

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Optimal design of steel skeletal structures using the enhanced genetic algorithm methodology

Tugrul TALASLIOGLU

Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 4,   Pages 863-889 doi: 10.1007/s11709-019-0523-9

Abstract: For this purpose, the enhanced genetic algorithm methodology named EGAwMP is utilized as an optimizationThe evolutionary search mechanism of EGAwMP is constituted on the basis of generational genetic algorithminto sub-populations and using of a radial basis neural network for dynamically adjustment of EGAwMP’s genetic

Keywords： design optimization     genetic algorithm     multiple populations     neural network    

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Research progress on genetic improvement of

Chuanping YANG

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 4,   Pages 391-401 doi: 10.15302/J-FASE-2017183

Abstract: Over the past 30 years, effective progress has been made in genetic improvement and molecular breedingmolecular markers were developed and the high density genetic map constructed.All this research has provided a model and data for the foundation of forest genetic improvement and

Keywords： Betula platyphylla     genetic improvement     molecular breeding     seed orchard    

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Factors affecting the distribution of microplastics in soils of China

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 9, doi: 10.1007/s11783-023-1710-4

Abstract:

● Microplastic (MP) abundance in soil of China was highly heterogeneous.

Keywords： Microplastic distribution     Microplastic heterogeneity     Effecting factors     Agriculture     Socio-economic    

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Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 240-262 doi: 10.1007/s11684-022-0936-z

Abstract: Thus, while genetic makeup may change during progression and/or within different tumor areas, adult gliomas

Keywords： glioma progression     molecular classification     EM/PM subtyping     intratumor heterogeneity    

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Genomics and genetic breeding in aquatic animals: progress and prospects

Wenteng XU, Songlin CHEN

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 305-318 doi: 10.15302/J-FASE-2017154

Abstract: focuses on dissection of genome structure and function to provide a molecular basis for understanding the geneticprogress of aquatic animals in nine aspects, including WGS and fine mapping, construction of high density genetic

Keywords： aquaculture     genomics     genetic breeding     progress    

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Title Author Date Type Operation

Heterogeneity of the tumor immune microenvironment and clinical interventions

Journal Article

Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and

Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang

Journal Article

Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype

Xu Chen, Xiaomao Xu, Fei Xiao

Journal Article

Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between

Na Qin, Yuancheng Li, Cheng Wang, Meng Zhu, Juncheng Dai, Tongtong Hong, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Gary Goodman, Stig E. Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeboller, Gadi Rennert, Susanne Arnold, Paul Brennan, John K. Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J. Hung, Angeline Andrew, Lambertus A. Kiemeney, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Penella Woll, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Victoria L. Stevens, Guangfu Jin, David C. Christiani, Zhibin Hu, Christopher I. Amos, Hongxia Ma, Hongbing Shen

Journal Article

Computational modeling of fracture in concrete: A review

Luthfi Muhammad Mauludin, Chahmi Oucif

Journal Article

Analysis of stress and failure in rock specimens with closed and open flaws on the surface

Journal Article

A multiscale material model for heterogeneous liquid droplets in solid soft composites

Journal Article

Heterogeneous influence of individuals’ behavior on mask efficacy in gathering environments

Journal Article

Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature

Journal Article

Interplay between diet and genetic susceptibility in obesity and related traits

Tiange Wang, Min Xu, Yufang Bi, Guang Ning

Journal Article

Optimal design of steel skeletal structures using the enhanced genetic algorithm methodology

Tugrul TALASLIOGLU

Journal Article

Research progress on genetic improvement of

Chuanping YANG

Journal Article

Factors affecting the distribution of microplastics in soils of China

Journal Article

Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Journal Article

Genomics and genetic breeding in aquatic animals: progress and prospects

Wenteng XU, Songlin CHEN

Journal Article